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A greater efficacy response of the combination therapy group was achieved with half the median daily dose of Prandin and rosiglitazone, as compared to the respective monotherapy groups. In this study where metformin dosage was kept constant, the combination therapy of Prandin and metformin showed dose-sparing effects with respect to Prandin. The greater efficacy response of the combination group was achieved at a lower daily repaglinide dosage than in the Prandin monotherapy group. It was also shown that Prandin can be administered at the start of a meal, 15 minutes before, or 30 minutes before the meal with the same blood glucose-lowering effect. There was no average gain in body weight when patients previously treated with oral hypoglycemic agents were switched to Prandin.
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